The five pillars of the Azure Well-Architected Framework are reliability, cost optimization, operational excellence, performance efficiency, and security. While each pillar is important, you can prioritize them based on your workload. Build and manage high-quality workloads using resources that align with Microsoft best practices, guided by the five pillars. These tools, programs, and guidance include the Azure Well-Architected Review, Azure Advisor, comprehensive documentation, partners, support, and service offers, the Azure Architecture Center, and the Well-Architected recommendation process.